Online Pharmacy

Buy Motilium (Generic)

Motilium is a medicine that increases the movements or contractions of the stomach and bowel. Motilium is also prescribed to treat nausea and vomiting caused by other drugs prescribed to treat Parkinson's Disease.

Buy Motilium

Motilium prescription

Motilium is indicated for:
-
Delayed gastric emptying of functional origin with gastro-oesophageal reflux and/or dyspepsia.

-
Control of nausea and vomiting of central or local origin.

-
As an anti-emetic in patients receiving cytostatic and radiation therapy.

-
Facilitates radiological examination of the upper gastro-intestinal tract.

How to take Motilium

Acute conditions (mainly nausea, vomiting, hiccup)
Adults: Two tablets (20 mg) 3 to 4 times per day, 15 to 30 minutes before meals and, if necessary, before retiring.
Children 5 to 12years old: One tablet (10mg) 3 to 4 times per day, 15 to 30minutes before meals and, if necessary, before retiring.
Chronic conditions (mainly dyspepsia)
Adults: One tablet (10 mg) taken 3 times per day, 15 to 30 minutes before meals and, if necessary, before retiring. The dosage may be doubled.
Children 5 to 12years old: ½tablet (5mg) 3to 4times per day, 15to 30minutes before meals and if necessary, before retiring.
This formulation is not suited for children under the age of 5years, but for this group of patients the suspension is available.

Motilium side effects

May occur:
- Urticaria;
- Rash;
- Dystonic reactions (extra pyramidal phenomena);
- Allergic reactions;
- Abdominal cramps have been reported;

Reversible raised serum prolactin levels have been observed which may lead to galactorrhoea and gynaecomastia.
Hypertensive crises in patients with phaeochromocytoma may occur with administration of Motilium.
Where the blood brain barrier is not fully developed (mainly in young babies) or is impaired, the possible occurrence of neurological side-effects cannot be totally excluded

Motilium precaution

Since Motilium is highly metabolised in the liver, Motilium should be prescribed with caution in patients with hepatic impairment (and in the elderly).
Motilium should be prescribed with caution in patients with renal impairment or in those at risk of fluid retention. In patients with severe renal insufficiency (serum creatinine more than 6mg/100ml, i.e. more than 0,6mmol/L) the elimination half-life of Motilium was increased from 7,4 to 20,8 hours. The dosing frequency should be reduced to once or twice daily, depending on the severity of impairment, and the dose may need to be reduced. Patients on prolonged therapy should be reviewed regularly

Motilium drug interactions

Concomitant administration of anti-cholinergic drugs may inhibit the anti-dyspeptic effects of Motilium.
Anti-muscarinic agents and opioid analgesics may antagonize the effect of Motilium.
Motilium suppresses the peripheral effects (digestive disorders, nausea and vomiting) of dopaminergic agonists.
Since Motilium has gastro-kinetic effects, it could influence the absorption of concomitant orally administered medicines, particularly those with sustained release or enteric coated formulations.
As Motilium interferes with serum prolactin levels, it may interfere with other hypoprolactinaemic agents and with some diagnostic tests.
Antacids and anti-secretory agents lower the oral bioavailability of Motilium. They should be taken after meals and not before meals, i.e. they should not be taken simultaneously with Motilium.
Reduced gastric acidity impairs the absorption of Motilium.
Oral bioavailability is decreased by prior administration of cimetidine or sodium bicarbonate.
The main metabolic pathway of Motilium is through CYP3A4. In vitro data suggests that concomitant use of drugs that significantly inhibit this enzyme may result in increased plasma levels of Motilium. Examples of CYP3A4 inhibitors include the following:
-
azole antifungals
-
macrolide antibiotics
-
HIV protease inhibitors
-
nefazodone

Motilium missed dose

If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Motilium storage

Store below 25 degrees away from moisture and sunlight. Do not store in the bathroom. Keep away from children and pets.